Neurodegenerative Disorder
Neurodegenerative Disorder are group of disorder which can effect the neurons of brain
Neurons
Neurons are basic structural and functional unit of human brain. Neuron consist of cell Body, dendrites and axons
Types of Neuron
Neurons
Neurons are basic structural and functional unit of human brain. Neuron consist of cell Body, dendrites and axons
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| Neuron |
- Unipolar Neuron
- Bipolar Neuron
- Artificial Neuron
Disorder of Nervous System
- Alzheimer's disease
- Parkinson's Disease
- Multiple sclerosis
- Prion Dieases
- Spinal Muscular Atrory
Alzheimer Disease
Alzheimer disease is neurodegenrative disorder characterized by tremors, muscular rigidity, bradykinesia and postural and gait abnormalities. Most cases involve people over the age of 65, among whom the incidence is about 1 in 100 individuals.
Etiology
The main cause of Parkinson disease is unknown in most patients. The disease is correlated with destruction of dopaminergic neurons in the substantia nigra with a consequent reduction of dopamine actions in the corpus striatum, parts of the brain’s basal ganglia system that are involved in motor control. The loss of dopamine neurons in the sub- stantia nigra is evidenced by diminished overall uptake of dopamine precursors in this region, which can be visualized
. Genetic factors do not play a dominant role in the etiology of Parkinson disease, although they may exert some influence on an individual’s susceptibility to the disease. It appears increasingly likely that an environmental factor may play a role in the loss of dopaminergic neurons.
Etiology
The main cause of Parkinson disease is unknown in most patients. The disease is correlated with destruction of dopaminergic neurons in the substantia nigra with a consequent reduction of dopamine actions in the corpus striatum, parts of the brain’s basal ganglia system that are involved in motor control. The loss of dopamine neurons in the sub- stantia nigra is evidenced by diminished overall uptake of dopamine precursors in this region, which can be visualized
. Genetic factors do not play a dominant role in the etiology of Parkinson disease, although they may exert some influence on an individual’s susceptibility to the disease. It appears increasingly likely that an environmental factor may play a role in the loss of dopaminergic neurons.
Parkinson's Disease
Alzheimer disease is only palliative and provides modest short-term benefit. Dementia of the Alzheimer type (versus the other forms of dementia that will not be addressed in this discussion, such as multi-infarct dementia or Lewy body dementia) has three distinguishing features: 1) accumulation of senile plaques (β-amyloid accumulations); 2) formation of numerous neurofibrillary tangles; and 3) loss of cortical neurons, particularly cholinergic neurons.
PD is the second most common neurodegenerative disease after Alzheimer’s disease (AD)
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